| 货号 | 16487-1g |
| 描述 | Hemin chloride is an oxidized form of heme that inhibits eukaryotic translation initiation factor 2α kinase 1 (eIF2αK1), a repressor of eIF-2α.1 This alters the initiation of mRNA translation, evoking a wide array of cellular effects. Hemin chloride is used experimentally to induce the expression of heme oxygenase-1 in cells and in animals.2,3,4 Heme extracted from blood is usually oxidized to hemin chloride.5,6 In porphyria, disorders resulting from an increase in porphyrins, hemin chloride serves to activate feedback inhibition of δ-aminolevulinic acid synthase, reducing heme biosynthesis.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Taraha, S.M.,Traugh, J.A.,Sharp, S.B., et al. Effect of hemin on site-specific phosphorylation of eukaryotic initiation factor 2. Proc. Natl. Acad. Sci. USA 75(2), 789-793 (1978). 2.Vesely, M.J.J.,Exon, D.J.,Clark, J.E., et al. Heme oxygenase-1 induction in skeletal muscle cells: hemin and sodium nitroprusside are regulators in vitro. Am. J. Physiol. 275(4 Pt 1), C1087-1094 (1998). 3.Lindenblatt, N.,Bordel, R.,Schareck, W., et al. Vascular heme oxygenase-1 induction suppresses microvascular thrombus formation in vivo. Arterioscler. Thromb. Vasc. Biol. 24(3), 601-606 (2004). 4.Botros, F.T.,Prieto-Carrasquero, M.C.,Martin, V.L., et al. Heme oxygenase induction attenuates afferent arteriolar autoregulatory responses. Am. J. Physiol. Renal Physiol. 295(4), F904-F911 (2008). 5.Labbé, R.F.,Finch, C.A.,Smith, N.J., et al. Erythrocyte protoporphyrin/heme ratio in the assessment of iron status. Clin. Chem. 25(1), 87-92 (1979). 6.Bissell, D.M. and Wang, B. Acute hepatic porphyria. J. Clin. Transl. Hepatol. 3(1), 17-26 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 2-8 |
| 纯度 | ≥96% |
| 计算分子量 | 652 |
| 分子式 | C34H30ClFeN4O4 • 2H |
| CAS号 | 16009-13-5 |
| 稳定性 | ≥ 2 years |
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