Promethazine (hydrochloride)
货号：
16478-10g 基本售价：
350.0 元 规格：
10 g
产品信息
概述| 货号 | 16478-10g |
| 描述 | Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively.1,2 Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM).1,2 Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea.3 |
| 别名 | Diprazin;Fellozine;Lergigan;Phenergan;Romergan; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kubo, N.,Shirakawa, S.,Kuno, T., et al. Antimuscarinic effects of antihistamines: Quantitative evaluation by receptor-binding assay. Japanese Journal of Pharmacology 43(3), 277-282 (1987).
2.Barnett, A.,Iorio, L.C.,Kreutner, W., et al. Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine. Agents and Actions 43(3-4), 149-156 (1994).
3.Nakayama, H.,Yamakuni, H.,Higaki, M., et al. Antiemetic activity of FK1052, a 5-HT3- and 5-HT4-receptor antagonist, in Suncus murinus and ferrets. Journal of Pharmacological Sciences 98(4), 396-403 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 320.9 |
| 分子式 | C17H20N2S • HCl |
| CAS号 | 58-33-3 |
| 稳定性 | ≥ 2 years |
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