| 货号 | 16476-100mg |
| 描述 | Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity.1,2 Also known as 4’-methyl genistein, biochanin A can be metabolized in vivo to genistein (Item No. 10005167), another phytoestrogen with diverse effects.3 Biochanin A also intersects with signaling through peroxisome proliferator-activated receptors (PPARs), as it activates PPARγ (IC50 = 19 µM) and has also been shown to activate a PPARα promoter.4 Moreover, it increases the expression of the PPARγ coactivator PGC-1α, promoting mitochondrial biogenesis.5 Biochanin A also inhibits fatty acid amide hydrolase (IC50 = 2.4 µM) and acts as an agonist of the aryl hydrocarbon receptor (EC50 = 0.25 µM).6,7 |
| 别名 | 4’-methyl Genistein;5,7-dihydroxy-4-Methoxyisoflavone;NSC 123538; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Evans, B.A.J.,Griffiths, K. and Morton, M.S. Inhibition of 5α-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. Journal of Endocrinology 147, 295-302 (1995). 2.Khan, S.I.,Zhao, J.,Khan, I.A., et al. Potential utility of natural products as regulators of breast cancer-associated aromatase promoters. Reproductive Biology and Endocrinology 9, 1-10 (2011). 3.Patisaul, H.B. and Jefferson, W. The pros and cons of phytoestrogens. Front.Neuroendocrinol. 31(4), 400-419 (2010). 4.Wang, L.,Waltenberger, B.,Pferschy-Wenzig, E.M., et al. Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): A review. Biochemical Pharmacology (2014). 5.Rasbach, K.A. and Schnellmann, R.G. Isoflavones promote mitochondrial biogenesis. Journal of Pharmacology and Experimental Therapeutics 325(2), 536-543 (2008). 6.Thors, L.,Burston, J.J.,Alter, B.J., et al. Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase. British Journal of Pharmacology 160(3), 549-560 (2010). 7.Medjakovic, S. and Jungbauer, A. Red clover isoflavones biochanin A and formononetin are potent ligands of the human aryl hydrocarbon receptor. Journal of Steroid Biochemistry and Molecular Biology 108(1-2), 171-177 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 284.3 |
| 分子式 | C16H12O5 |
| CAS号 | 491-80-5 |
| 稳定性 | ≥ 2 years |
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