| 货号 | 16472-10mg |
| 描述 | Pyrimethamine is an antiprotozoal agent that is primarily active against P. falciparum, inhibiting the protozoal enzyme dihydrofolate reductase (DHFR).1 By blocking DHFR activity, pyrimethamine prevents the production of tetrahydrofolic acid, an essential coenzyme involved in DNA and RNA synthesis. In in vivo antimalarial mouse models, pyrimethamine displays a prophylactic effect at an ED50 value of 0.5 mg/kg.2 Sulphonamides act synergistically with pyrimethamine by arresting production of dihydrofolic acid, resulting in the sequential blockade of the folate pathway of protozoa.3 Pyrimethamine has also been found to limit the expression of the superoxide dismutase 1 (SOD1) gene, a metalloenzyme involved in amyotrophic lateral sclerosis.4 |
| 别名 | Darapram;Daraprim®;Khloridin;NSC 3061; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Peters, W. Chemoprophylaxis and chemotherapy. Brit.Med.J. 2, 95-98 (1971). 2.Adebajo, A.C.,Odediran, S.A.,Aliyu, F.A., et al. In vivo antiplasmodial potentials of the combinations of four nigerian antimalarial plants. Molecules 19(9), 13136-13146 (2014). 3.Hwang, J.,Bitarakwate, E.,Pai, M., et al. Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: A systematic review. Trop.Med.Int.Health 11(6), 789-799 (2006). 4.Limpert, A.S.,Mattmann, M.E. and Cosford, N.D.P. Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS). Beilstein J.Org.Chem. 9, 717-732 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 248.7 |
| 分子式 | C12H13ClN4 |
| CAS号 | 58-14-0 |
| 稳定性 | ≥ 2 years |
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