| 货号 | 16439-1mg |
| 描述 | Lysine-specific demethylase 1 (LSD1) belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs) and polyamine oxidase (PAO).1 LSD1 specifically demethylates mono- and dimethylated histone H3 lysine 4, resulting in transcriptional repression.2 It also controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS370).3 GSK-LSD1 is an irreversible, mechanism-based inhibitor of LSD1 (IC50 = 16 nM) that is >1,000-fold selective over the closely related FAD-utilizing enzymes LSD2, MAO-A, and MAO-B.4 GSK-LSD1 induces gene expression changes in various cancer cell lines, inhibiting their proliferation (EC50s<5 nM).4 See the Structural Genomics Consortium (SGC) website for more information. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shi, Y.,Lan, F.,Matson, C., et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119, 941-953 (2004). 2.Forneris, F.,Binda, C.,Vanoni, M.A., et al. Human histone demethylase LSD1 reads the histone code. The Journal of Biological Chemisty 280(50), 41360-41365 (2005). 3.Huang, J.,Sengupta, R.,Espejo, A.B., et al. p53 is regulated by the lysine demethylase LSD1. Nature 449, 105-108 (2007). 4.. Epigenetics probes collection. (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 289.2 |
| 分子式 | C14H20N2 • 2HCl |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |