| 货号 | 16402-1mg |
| 描述 | Tetrahydrouridine is a competitive, reversible inhibitor of cytidine deaminase (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively).1,2 Its use, alone or in combination with the DNA methyltransferase inhibitor 5-fluoro-2’-deoxycytidine, is being evaluated in animal models and clinical trials for diseases, including cancer and mitochondrial DNA depletion syndrome.3,4,5 |
| 别名 | NSC 112907;THU; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chabner, B.A.,Johns, D.G.,Coleman, C.N., et al. Purification and properties of cytidine deaminase from normal and leukemic granulocytes. J.Clin.Invest. 53(3), 922-931 (1974). 2.Cohen, R.M. and Woldender, R. Cytidine deaminase from Escherichia coli. Purification, properties and inhibition by the potential transition state analog 3,4,5,6-tetrahydrouridine. J.Biol.Chem. 246(24), 7561-7656 (1971). 3.Cámara, Y.,González-Vioque, E.,Scarpelli, M., et al. Administration of deoxyribonucleosides or inhibition of their catabolism as a pharmacological approach for mitochondrial DNA depletion syndrome. Hum.Mol.Genet. 23(9), 2459-2467 (2014). 4.Newman, E.M.,Morgan, R.J.,Kummar, S., et al. A phase I, pharmacokinetic, and pharmacodynamic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2-deoxycytidine, administered with tetrahydrouridine. Cancer Chemother. Pharmacol. 75(3), 537-546 (2015). 5.Yang, X.,Lay, F.,Han, H., et al. Targeting DNA methylation for epigenetic therapy. Trends in Pharamacological Sciences 31(11), 536-546 (2010). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥80% |
| 计算分子量 | 248.2 |
| 分子式 | C9H16N2O6 |
| CAS号 | 18771-50-1 |
| 稳定性 | ≥ 2 years |
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