| 货号 | 16390-100ug |
| 描述 | 8-iso-15-keto Prostaglandin F2α(8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-isoPGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-isoPGF2α) is a prostaglandin-like product of non-specific lipid peroxidation.1 In both humans and monkeys, exogenously infused 8-isoPGF2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation.2 A similar pattern is observed when tritiated 8-isoPGF2α is infused into rabbits.3 Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF2α was a major component of the metabolite profile, which was comprised mostly of unmetabolized 8-isoPGF2α. 8-iso -15-keto PGF2α is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.4 |
| 别名 | 8-iso-15-keto PGF2α;8-epi-15-keto PGF2α; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Morrow, J.D.,Hill, K.E.,Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proceedings of the National Academy of Sciences of the United States of America 87, 9383-9387 (1990). 2.Chiabrando, C.,Valagussa, A.,Rivalta, C., et al. Identification and measurement of endogenous β-oxidation metabolites of 8-epi-prostaglandin F2α. The Journal of Biological Chemisty 274, 1313-1319 (1999). 3.Basu, S. Metabolism of 8-iso-prostaglandin F2α. FEBS Letters 428, 32-36 (1998). 4.Cracowski, J.L.,Camus, L.,Durand, T., et al. Response of rat thoracic aorta to F2-isoprostane metabolites. Journal of Cardiovascular Pharmacology 39, 396-403 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 352.5 |
| 分子式 | C20H32O5 |
| CAS号 | 191919-01-4 |
| 稳定性 | ≥ 1 year |
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