| 货号 | 16329-1mg |
| 描述 | BIO-Acetoxime is an analog of the GSK3 inhibitor 6-bromoindirubin-3’-oxime, or BIO (Item No. 13123).1,2 It potently inhibits GSK3α/β (IC50 = 10 nM), with selectivity over Cdk5/p25, Cdk2/A, and Cdk1/B (IC50s = 2.4, 4.3, and 63 µM, respectively).1,2 BIO-Acetoxime has been used to study the role of GSK3 in the Wnt/β-catenin pathway.3 It also suppresses the cytopathic effects of herpes viruses and reduces viral yields in human oral epithelial cells.4 |
| 别名 | 6-Bromoindirubin-3-acetoxime;GSK3 Inhibitor X; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Meijer, L.,Skaltsounis, A.L.,Magiatis, P., et al. GSK-3-selective inhibitors derived from tyrian purple indirubins. Chemistry & Biology 10, 1255-1266 (2003). 2.Polychronopoulos, P.,Magiatis, P.,Skaltsounis, A.L., et al. Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. Journal of Medicinal Chemistry 47, 935-946 (2004). 3.Wang, B.,Liu, J.,Ma, L.N., et al. Chimeric 5/35 adenovirus-mediated Dickkopf-1 overexpression suppressed tumorigenicity of CD44+ gastric cancer cells via attenuating Wnt signaling. J.Gastroenterol. 48, 798-808 (2013). 4.Hsu, M.J. and Hung, S.L. Antiherpetic potential of 6-bromoindirubin-3-acetoxime (BIO-acetoxime) in human oral epithelial cells. Archives of Virology 158, 1287-1296 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 398.2 |
| 分子式 | C18H12BrN3O3 |
| CAS号 | 740841-15-0 |
| 稳定性 | ≥ 2 years |
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