TDZD-8
货号：
16287-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16287-1mg |
| 描述 | TDZD-8 is a thiadiazolidine derivative that acts as a non-ATP competitive inhibitor of the serine/threonine kinase glycogen synthase kinase 3β (GSK3β; IC50 = 2 µM), binding to the active site of GSK3β.1 It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, cAMP-dependent protein kinase, or protein kinase C (IC50s = >100 µM).1 TDZD-8 has been used to study the role of GSK3β during stem cell differentiation as well as in cell and animal models of Alzheimer’s disease and other neurodegenerative disorders.2,3 |
| 别名 | GSK3β Inhibitor I;NP 01139; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Martinez, A.,Alonso, M.,Castro, A., et al. First non-ATP competitive glycogen synthase kinase 3 β (GSK-3β) inhibitors: Thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer’s disease. Journal of Medicinal Chemistry 45(6), 1292-1299 (2002).
2.Guzman, M.L.,Li, X.,Corbett, C.A., et al. Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8). Blood 110(13), 4436-4444 (2007).
3.Eldar-Finkelman, H. and Martinez, A. GSK-3 inhibitors: Preclinical and clinical focus on CNS. Front.Mol.Neurosci. 4, 1-18 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 222.3 |
| 分子式 | C10H10N2O2S |
| CAS号 | 327036-89-5 |
| 稳定性 | ≥ 2 years |
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