TAK-632
货号：
16285-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16285-1mg |
| 描述 | TAK-632 is a slow off-rate inhibitor of Raf kinases (IC50s = 8.3, 2.4, and 1.4 nM for wild type B-Raf, mutant B-RafV600E, and c-Raf, respectively).1 It demonstrates 14-1,200-fold selectivity for Raf over a panel of 26 different kinases.1 TAK-632 shows significant antiproliferative activity against mutated B-Raf or mutated N-Ras cancer cell lines and xenograft models, inhibiting MEK phosphorylation with an IC50 value of 12 nM and downstream ERK phosphorylation with an IC50 value of 16 nM.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Okaniwa, M.,Hirose, M.,Arita, T., et al. Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: Design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives. Journal of Medicinal Chemistry 56(16), 6478-6494 (2013).
2.Nakamura, A.,Arita, T.,Tsuchiya, S., et al. Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanoma. Cancer Research 73(23), 7043-7055 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 554.5 |
| 分子式 | C27H18F4N4O3S |
| CAS号 | 1228591-30-7 |
| 稳定性 | ≥ 2 years |
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