PD 0332991 (hydrochloride)
货号：
16273-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16273-1mg |
| 描述 | PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases.1 It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest at nanomolar concentrations.1 PD 0332991 can inhibit the growth of certain ER-positive or HER2-amplified breast cancer cells (IC50s as low as 4 nM) and demonstrates synergy with tamoxifen (Item No. 13258) and trastuzumab, respectively.2 Recently, PD 0332991 inhibition of Cdk4 activity has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism that is independent of cell cycle progression.3 |
| 别名 | Palbociclib; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fry, D.W.,Harvey, P.J.,Keller, P.R., et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Molecular Cancer Therapeutics 3(11), 1427-1438 (2004).
2.Finn, R.S.,Dering, J.,Conklin, D., et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Research 11(5), 1-13 (2009).
3.Lee, Y.,Dominy, J.E.,Choi, Y.J., et al. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature 510(7506), 547-551 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 484 |
| 分子式 | C24H29N7O2 • HCl |
| CAS号 | 827022-32-2 |
| 稳定性 | ≥ 2 years |
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