| 货号 | 16265-1mg |
| 描述 | While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling.1 Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology.2 MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1.3,4,5 It has been used in cells (1-10 µM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.5,6,7,8,9,10 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.de Ruijter, A.J.,van Gennip, A.H.,Caron, H.N., et al. Histone deacetylases (HDACs): Characterization of the classical HDAC family. Biochemistry Journal 370(Pt 3), 737-749 (2003). 2.Yang, X.J. and Grégoire, S. Class II histone deacetylases: From sequence to function, regulation, and clinical implication. Molecular and Cellular Biology 25(8), 2873-2884 (2005). 3.Mai, A.,Massa, S.,Pezzi, R., et al. Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. Journal of Medicinal Chemistry 48(9), 3344-3353 (2005). 4.Mai, A.,Jelicic, K.,Rotili, D., et al. Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia. Molecular Pharmacology 72(5), 1111-1123 (2007). 5.Nebbioso, A.,Manzo, F.,Miceli, M., et al. Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. EMBO reports 10(7), 776-782 (2009). 6.Duong, V.,Bret, C.,Altucci, L., et al. Specific activity of class II histone deacetylases in human breast cancer cells. Molecular Cancer Research 6(12), 1908-1919 (2008). 7.Nebbioso, A.,DellAversana, C.,Bugge, A., et al. HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation. Journal of Molecular Endocrinology 45(4), 219-228 (2010). 8.Wang, G.,He, J.,Zhao, J., et al. Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer. PLoS One 7(12), 1-10 (2012). 9.Mannaerts, I.,Eysackers, N.,Onyema, O.O., et al. Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29. PLoS One 8(1), 1-9 (2013). 10.Spallotta, F.,Tardivo, S.,Nanni, S., et al. Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia. The Journal of Biological Chemisty 288(32), 22915-22929 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 314.3 |
| 分子式 | C17H15FN2O3 |
| CAS号 | 852475-26-4 |
| 稳定性 | ≥ 2 years |
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