GNF-5
货号：
16254-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 16254-5mg |
| 描述 | Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia. GNF-5 is the N-hydroxyethyl carboamide analog of GNF-2 (Item No. 16253), a selective allosteric inhibitor of Bcr-Abl.1,2 GNF-5 demonstrates IC50 values of 4.52, 0.38, and 0.93 µM against Bcr-Abl mutants G250E, E255V, and M351T, respectively.1 When used in combination with the ATP-competitive Bcr-Abl inhibitors imatinib (Item No. 13139) or nilotinib (Item No. 10010422), GNF-5 displays additive inhibitory activity against T315I Bcr-Abl mutants both in in vitro assays and in a recalcitrant T315I Bcr-Abl mutant mouse bone marrow transplantation model.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhang, J.,Adrián, F.J.,Jahnke, W., et al. Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature 463(7280), 501-506 (2010).
2.Adrián, F.J.,Ding, Q.,Sim, T., et al. Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nature Chemical Biology 2(2), 95-102 (2006).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 418.4 |
| 分子式 | C20H17F3N4O3 |
| CAS号 | 778277-15-9 |
| 稳定性 | ≥ 2 years |
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