AZD 9291
货号：
16237-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16237-1mg |
| 描述 | AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM).1 It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 µM, respectively).1 AZD 9291 has been shown to inhibit tumor growth in a xenograft mouse model at oral doses of 5-10 mg/kg and has been tested clinically in patients with advanced EGFR mutant non-small-cell lung cancer.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Finlay, M.R.,Anderton, M.,Ashton, S., et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. Journal of Medicinal Chemistry 57(20), 8249-8267 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 499.6 |
| 分子式 | C28H33N7O2 |
| CAS号 | 1421373-65-0 |
| 稳定性 | ≥ 2 years |
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