trans-Urocanic Acid
货号：
16228-1g 基本售价：
350.0 元 规格：
1 g
产品信息
概述| 货号 | 16228-1g |
| 描述 | trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine.1 It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis.1 Upon UVB exposure, trans-urocanic acid is converted to the cis isomer, which is known to activate regulatory T cells.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gibbs, N.K. and Norval, M. Urocanic acid in the skin: a mixed blessing? Journal of Investigative Dermatology 131(1), 14-17 (2011).
2.Schwartz, T. Mechanisms of UV-induced immunosuppression. Keio J.Med. 54(4), 165-171 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 138.1 |
| 分子式 | C6H6N2O2 |
| CAS号 | 3465-72-3 |
| 稳定性 | ≥ 2 years |
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