| 货号 | 16226-1mg |
| 描述 | Apoptosis signal-regulating kinase 1 (ASK1) is the ubiquitously expressed mitogen-activated protein kinase kinase kinase 5 involved in a wide range of biological functions that are dependent on cell survival or death.1,2 NQDI-1 is a specific inhibitor of ASK1 (IC50 = 3 μM; Ki = 500 nM) that demonstrates potent selectivity against various serine/threonine and tyrosine protein kinases.2 It has been used to promote survival of induced pluripotent stem cell populations and to protect neurons from reactive oxygen species-induced apoptosis in a model of ischemia.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Charette, S.J.,Lambert, H. and Landry, J. A kinase-independent function of Ask1 in caspase-independent cell death. The Journal of Biological Chemisty 276(39), 36071-36074 (2001). 2.Volynets, G.P.,Chekanov, M.O.,Synyugin, A.R., et al. Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). Journal of Medicinal Chemistry 54(8), 2680-2686 (2011). 3.Yoshida, T.,Ozawa, Y.,Suzuki, K., et al. The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa. Mol.Brain 7, 1-11 (2014). 4.Nomura, K.,Lee, M.,Banks, C., et al. An ASK1-p38 signalling pathway mediates hydrogen peroxide-induced toxicity in NG108-15 neuronal cells. Neuroscience Letters 549, 163-167 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 319.3 |
| 分子式 | C19H13NO4 |
| CAS号 | 175026-96-7 |
| 稳定性 | ≥ 2 years |
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