NU 6027
货号：
16177-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16177-1mg |
| 描述 | Cyclin-dependent kinases (CDKs) play a key role in regulating cell division by phosphorylating distinct substrates in different phases of the cell cycle. Cell cycle deregulation in many cancers often results from altered CDK activity. Thus, CDKs are potential pharmacological targets for anticancer agents. NU 6027 inhibits both CDK1 and CDK2 with IC50 values of 2.9 and 2.2 µM, respectively.1 It has been shown to inhibit cellular ataxia telangiectasia mutated and Rad3-realted kinase activity (IC50 = 6.7 µM) and impair G2/M arrest in various human cancer cells, potentiating the cytotoxic effects of DNA-damaging, anticancer agents such as cisplatin.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sayle, K.L.,Bentley, J.,Boyle, F.T., et al. Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2. Bioorganic & Medicinal Chemistry Letters 13(18), 3079-3082 (2003).
2.Peasland, A.,Wang, L.Z.,Rowling, E., et al. Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. British Journal of Cancer 105(3), 372-381 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 251.3 |
| 分子式 | C11H17N5O2 |
| CAS号 | 220036-08-8 |
| 稳定性 | ≥ 2 years |
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