ISX-9
货号：
16165-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16165-1mg |
| 描述 | ISX-9 is a small molecule inducer of adult neural stem cell differentiation both in vitroandin vivo. At 2.5-20 µM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.1,2,3 ISX-9 administered at 20 mg/kg for 12 days to mice has been reported to improve hippocampal function as evidenced by enhanced spatial memory ability in the Morris water maze test.3 |
| 别名 | Isoxazole 9;Neuronal Differentiation Inducer III; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schneider, J.W.,Gao, Z.,Li, S., et al. Small-molecule activation of neuronal cell fate. Nature Chemical Biology 4(7), 408-410 (2008).
2.Li, H.,Radford, J.C.,Ragusa, M.J., et al. Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proceedings of the National Academy of Sciences of the United States of America 105(27), 9397-9402 (2008).
3.Petrik, D.,Jiang, Y.,Birnbaum, S.G., et al. Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule. The FASEB Journal 26(8), 3148-3162 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 234.3 |
| 分子式 | C11H10N2O2S |
| CAS号 | 832115-62-5 |
| 稳定性 | ≥ 2 years |
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