| 货号 | 16162-1mg |
| 描述 | γ-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis. LY411575 is a cell-permeable γ-secretase inhibitor (IC50 = 0.14 nM) that has been shown to block Notch activation in vitro at 500 µM.1,2 LY411575 can induce apoptosis in Kaposi’s sarcoma cells as well as promote intestinal goblet cell differentiation in a mouse model of colitis.2,3 It has also been observed to promote neural differentiation of mouse embryonic stem cells.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Czirr, E.,Leuchtenberger, S.,Dorner-Ciossek, C., et al. Insensitivity to Aβ42-lowering nonsteroidal anti-inflammatory drugs and γ-secretase inhibitors is common among aggressive presenilin-1 mutations. J.Bio.Chem. 282(34), 24504-24513 (2007). 2.Curry, C.L.,Reed, L.L.,Golde, T.E., et al. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi’s sarcoma tumor cells. Oncogene 24(42), 6333-6344 (2005). 3.Okamoto, R.,Tsuchiya, K.,Nemoto, Y., et al. Requirement of Notch activation during regeneration of the intestinal epithelia. American Journal of Physiology and Gastrointestinal Liver Physiology 296(1), G23-G35 (2009). 4.Abranches, E.,Silva, M.,Pradier, L., et al. Neural differentiation of embryonic stem cells in vitro: A road map to neurogenesis in the embryo. PLoS One 4(7), e6286 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 479.5 |
| 分子式 | C26H23F2N3O4 |
| CAS号 | 209984-57-6 |
| 稳定性 | ≥ 2 years |
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