| 货号 | 16160-1mg |
| 描述 | Acetyl Coenzyme A (acetyl-CoA), the thioester of CoA (Item No. 16147) and acetic acid, is a pivotal molecule in biological systems. Foremost, it serves as a source of carbon for the Krebs cycle, for the synthesis of fatty acids, and for isoprenoid-based protein modifications.1,2,3,4 Acetyl-CoA also serves as an intermediate in oxidation of fatty acids and amino acids and is formed by the oxidative decarboxylation of pyruvate in mitochondria.5 It is an essential cofactor or substrate for acetyltransferases and acyltransferases, as in the post-translational modification of proteins and in the synthesis of the neurotransmitter acetylcholine.2,3 |
| 别名 | Acetyl-CoA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Akram, M. Citric acid cycle and role of its intermediates in metabolism. Cell Biochemistry and Biophysics 68(3), 475-478 (2014). 2.Salminen, A.,Kauppinen, A.,Hiltunen, M., et al. Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process. Ageing Res.Rev. 16C, 45-65 (2014). 3.Zaidi, N.,Swinnen, J.V. and Smans, K. ATP-citrate lyase: A key player in cancer metabolism. Cancer Research 72(15), 3709-3714 (2012). 4.Palsson-McDermott, E.M. and ONeill, L.A. The Warburg effect then and now: From cancer to inflammatory diseases. BioEssays 35(11), 965-973 (2013). 5.Miura, Y. The biological significance of ω-oxidation of fatty acids. Proc.Jpn.Acad.Ser.B Phys.Biol.Sci. 89(8), 370-382 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 878.5 |
| 分子式 | C23H38N7O17P3S • 3Na |
| CAS号 | 102029-73-2 |
| 稳定性 | ≥ 2 years |
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