| 货号 | 16143-50mg |
| 描述 | Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis.1 It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events.1,2,3,4 Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain.3,1 It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-glycoprotein.5,6 |
| 别名 | Cucoline;NSC 76021; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wang, Q. and Li, X.K. Immunosuppressive and anti-inflammatory activities of sinomenine. International Immunopharmacology 11(3), 373-376 (2011). 2.Mayeda, H. The site of histamine release by sinomenine. Japanese Journal of Pharmacology 3(2), 73-81 (1954). 3.Sun, Y.,Yao, Y. and Ding, C.z. A combination of sinomenine and methotrexate reduces joint damage of collagen induced arthritis in rats by modulating osteoclast-related cytokines. International Immunopharmacology 18(1), 135-141 (2014). 4.Xu, M.,Liu, L.,Qi, C., et al. Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: A systematic review and meta-analysis. Planta Medica 74(12), 1426-1429 (2008). 5.Kesarwani, K.,Gupta, R. and Mukerjee, A. Bioavailability enhancers of herbal origin: An overview. Asian Pac.J.Trop.Biomed 3(4), 253-266 (2013). 6.Liu, Z.,Duan, Z.J.,Chang, J.Y., et al. Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression. PLoS One 9(6), 1-9 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 365.9 |
| 分子式 | C19H23NO4 • HCl |
| CAS号 | 6080-33-7 |
| 稳定性 | ≥ 2 years |
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