| 货号 | 16136-10mg |
| 描述 | Sotalol is a non-selective antagonist of β-adrenergic receptors that blocks β1-, β2-, and β3-adrenoceptors with IC50 values ranging between 0.1 and 8.9 µM.1,2,3 Through its effects on β2-adrenoceptors, sotalol also blocks outward potassium currents in myocardium, exhibiting Class III antiarrhythmic actions.4,5 |
| 别名 | Betapace®;MJ1999; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tsuchihashi, H.,Nakashima, Y.,Kinami, J., et al. Characteristics of I-iodocyanopindolol binding to β-adrenergic and serotonin-1B receptors of rat brain: Selectivity of β-adrenergic agents. Japan.J.Pharmacol. 52, 195-200 (1990). 2.Lis, R.,Morgan, T.K., Jr.,Marisca, A.J., et al. Synthesis of novel (aryloxy) propanolamines and related compounds possessing both class II and class III antiarrhythmic activity. J.Med.Chem 33, 2883-2891 (1990). 3.Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005). 4.Campbell, T.J. and Williams, K.M. Therapeutic drug monitoring: Antiarrhythmic drugs. British Journal of Clinical Pharmacology 46, 307-319 (1998). 5.Khairy, P. and Nattel, S. New insights into the mechanisms and management of atrial fibrillation. Can.Med.Assoc.J. 167(9), 1012-1020 (2002). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 308.8 |
| 分子式 | C12H20N2O3S • HCl |
| CAS号 | 959-24-0 |
| 稳定性 | ≥ 2 years |
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