| 货号 | 16133-50mg |
| 描述 | Procarbazine is a methyl hydrazine derivative that is converted by metabolism into a methylating species which converts DNA to various DNA adducts, including O6-methylguanine.1 While this process is mutagenic and carcinogenic, procarbazine is used with the compounds mechlorethamine, vincristine, also known as oncovin (Item No. 11764), and prednisone as part of the MOPP regimen for fighting Hodgkin disease.1,2,3 Procarbazine also has utility, in combination with other agents, in reducing the frequency of epileptic seizures in patients with pharmacoresistant epilepsy.4 |
| 别名 | Indicarb;Matulane®;Natulan;NSC 77213; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kyrtopoulos, S.A. Variability in DNA repair and individual susceptibility to genotoxins. Clinical Chemistry 41(12 Pt 2), 1848-1853 (1995). 2.Bonadonna, G. Chemotherapy strategies to improve the control of Hodgkin’s disease: The Richard and Hinda Rosenthal Foundation Award lecture. Cancer Research 42(11), 4309-4320 (1982). 3.Erikson, J.M.,Tweedie, D.J.,Ducore, J.M., et al. Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells. Cancer Research 49(1), 127-133 (1989). 4.Rudà, R.,Bello, L.,Duffau, H., et al. Seizures in low-grade gliomas: Natural history, pathogenesis, and outcome after treatments. Neuro.Oncol. 14(Suppl 4), 55-64 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 257.8 |
| 分子式 | C12H19N3O • HCl |
| CAS号 | 366-70-1 |
| 稳定性 | ≥ 2 years |
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