| 货号 | 16129-500mg |
| 描述 | Chlorpromazine (CPZ) is a phenothiazine classified as an antipsychotic compound.1 It antagonizes a range of receptors, including post-synaptic dopamine (D) and serotonin (5-HT) receptors (Kis = 0.66, 0.84, 1.2, and 1.8 nM for D2, D3, D4, and 5-HT2A, respectively).2,3 CPZ also antagonizes histamine (H), α1- and α2-adrenergic, and muscarinic acetylcholine (M) receptors (Kis = 6, 0.28, 27, 46, and 47 nM for H1, α1A, α2B, α2C, and M3, respectively).4 |
| 别名 | CPZ;Largactil;Promacid;Thorazine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lepping, P.,Sambhi, R.S.,Whittington, R., et al. Clinical relevance of findings in trials of antipsychotics: Systematic review. British Journal of Psychiatry 198(5), 341-345 (2011). 2.Seeman, P. and Tallerico, T. Antipsychotic drugs which elicit little or no Parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors. Molecular Psychiatry 3(2), 123-134 (1998). 3.Seeman, P.,Corbett, R. and Van Tol, H.H. Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. Neuropsychopharmacology 16(2), 93-110 (1997). 4.Kroeze, W.K.,Hufeisen, S.J.,Popadak, B.A., et al. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28(3), 519-526 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 355.3 |
| 分子式 | C17H19ClN2S • HCl |
| CAS号 | 69-09-0 |
| 稳定性 | ≥ 2 years |
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