| 货号 | 16114-5mg |
| 描述 | 5-hydroxy Tryptophol is a metabolite of tryptophan that is formed by the alcohol dehydrogenase-catalyzed reduction of the serotonin (Item No. 14332) intermediate, 5-hydroxyindoleacetaldehyde.1,2,3 Depending on the tissue NAD/NADH ratio, the acetaldehyde intermediate can also be oxidized by aldehyde dehydrogenase to form 5-hydroxyindoleacetic acid.2,4,5 Thus, a ratio of 5-hydroxy tryptophol to 5-hydroxyindoleacetic acid has been used as a biomarker for recent alcohol consumption.4,5 |
| 别名 | NSC 84416; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yokoyama, M.T. and Carlson, J.R. Dissimilation of tryptophan and related indolic compounds by ruminal microorganisms in vitro. Appl.Microbiol. 27(3), 540-548 (1974). 2.Pletscher, A. Metabolism, transfer and storage of 5-hydroxytryptamine in blood platelets. Br.J.Pharmacol.Chemother. 32(1), 1-16 (1968). 3.Curzon, G.,Fernando, J.C.R. and Marsden, C.A. 5-Hydroxytryptamine: The effects of impaired synthesis on its metabolism and release in rat. British Journal of Pharmacology 63(4), 627-634 (1978). 4.Tekes, K. HPLC determination of serotonin and its metabolites from human platelet-rich plasma; shift to 5-hydroxytryptophol formation following alcohol consumption. J.Chromatogr.Sci. 46(2), 169-173 (2008). 5.Beck, O.,Stephanson, N.,Bötthcer, M., et al. Biomarkers to disclose recent intake of alcohol: Potential of 5-hydroxytryptophol glucuronide testing using new direct UPLC-tandem MS and ELISA methods. Alcohol & Alcoholism 42(4), 321-325 (2007). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 177.2 |
| 分子式 | C10H11NO2 |
| CAS号 | 154-02-9 |
| 稳定性 | ≥ 2 years |
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