TIQ-A
货号：
16112-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 16112-500ug |
| 描述 | Poly(ADP-ribose) polymerase 1 (PARP1) is a critical DNA repair enzyme involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis.1,2,3 TIQ-A is a PARP1 inhibitor (IC50 = 450 nM in cultured mouse cortical neurons).1 It displays neuroprotective effects in cultured mouse cortical neurons injured by oxygen-glucose deprivation (IC50 = 0.15 µM). TIQ-A has been used to inhibit eosinophilic infiltration into airways of OVA-challenged mice and to induce the regression of atherosclerotic plaques in high-fat fed apolipoprotein E(-/-) mice.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chiagurgi, A.,Meli, E.,Calvani, M., et al. Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) Polymerase-1: Pharmacological Characterization and Neuroprotective Effects in an in Vitro Model of Cerebral Ischemia. Journal of Pharmacology and Experimental Therapeutics 305(5), 943-949 (2014).
2.Oumouna, M.,Datta, R.,Oumouna-Benachour, K., et al. Poly(ADP-ribose) polymerase-1 inhibition prevents eosinophil recruitment by modulating Th2 cytokines in a murine model of allergic airway inflammation: A potential specific effect on IL-5. Journal of Immunology 177(9), 6489-6496 (2006).
3.Hans, C.P.,Zerfaoui, M.,Naura, A.S., et al. Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: Effects on inflammatory markers and lipid content. Journal of Pharmacology and Experimental Therapeutics 329(1), 150-158 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 201.2 |
| 分子式 | C11H7NOS |
| CAS号 | 420849-22-5 |
| 稳定性 | ≥ 2 years |
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