TIC10
货号：
16109-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16109-1mg |
| 描述 | TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 µM in a p53-independent manner.1 It is orally active, stable, and crosses the blood-brain barrier.1 The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor FOXO3a.1 TIC10 suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice.1 |
| 别名 | ONC201; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Allen, J.E.,Krigsfeld, G.,Mayes, P.A., et al. Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects. Sci.Transl.Med. 5(171), 1-14 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 386.5 |
| 分子式 | C24H26N4O |
| CAS号 | 1616632-77-9 |
| 稳定性 | ≥ 2 years |
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