| 货号 | 16087-1g |
| 描述 | Clomiphene is a selective estrogen receptor modulator that impairs the activation of estrogen receptors (ERs) by 17β-estradiol.1,2 It potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM, respectively).3 Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation.4,1 |
| 别名 | Clomifene;Omifin;NSC 35770; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Goldstein, S.R.,Siddhanti, S.,Ciaccia, A.V., et al. A pharmacological review of selective oestrogen receptor modulators. Hum.Reprod.Update 6(3), 212-224 (2000). 2.Amita, M.,Takahashi, T.,Tsutsumi, S., et al. Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate. Endocrinology 151(1), 394-405 (2010). 3.Kuiper, G.G.J.M.,Carlsson, B.,Grandien, K., et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138(3), 863-870 (1997). 4.Kousta, E.,White, D.M. and Franks, S. Modern use of clomiphene citrate in induction of ovulation. Hum.Reprod.Update 3(4), 359-365 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 598.1 |
| 分子式 | C26H28ClNO • C6H8O7 |
| CAS号 | 50-41-9 |
| 稳定性 | ≥ 2 years |
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