| 货号 | 16019-25mg |
| 描述 | Zalcitabine is an analog of pyrimidine derived from deoxycytidine with the replacement of the hydroxyl group in position 3’ with a hydrogen.1 In cells, it is phosphorylated to the active triphosphate form, ddCTP, which acts as a substrate for HIV reverse transcriptase (Ki = 51 nM).2,3 It incorporates into viral DNA where it terminates chain elongation when the missing hydroxyl group is encountered. Zalcitabine was the third antiretroviral approved by the FDA for treatment of HIV infection and AIDS.4 |
| 别名 | ddC;2’,3’-Dideoxycytidine;Hivid;NSC 606170;Ro 24-2027/000; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mitsuya, H. and Broder, S. Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2,3-dideoxynucleosides (acquired immunodeficiency syndrome). Proceedings of the National Academy of Sciences of the United States of America 83, 1911-1915 (1986). 2.Starnes, M.C. and Cheng, Y.C. Cellular metabolism of 2,3-dideoxycytidine, a compound active against human immunodeficiency virus in vitro. The Journal of Biological Chemisty 262(3), 988-991 (1987). 3.Boyle, N.A.,Rajwanshi, V.K.,Prhavc, M., et al. Synthesis of 2,3-dideoxynucleoside 5-α-P-borano-β,γ-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. Journal of Medicinal Chemistry 48(7), 2695-2700 (2005). 4.Bavinger, C.,Bendavid, E.,Niehaus, K., et al. Risk of cardiovascular disease from antiretroviral therapy for HIV: A systematic review. PLoS One 8(3), e59551 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 211.2 |
| 分子式 | C9H13N3O3 |
| CAS号 | 7481-89-2 |
| 稳定性 | ≥ 2 years |
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