Camostat (mesylate)
货号：
16018-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 16018-5mg |
| 描述 | Camostat is a trypsin-like protease inhibitor known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein, and thrombin. A special diet containing 1 mg/g camostat has been shown to inhibit the production of TNF-α and monocyte chemoattractant protein-1 by monocytes and to disrupt proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.1 Protease regulation via camostat has also been reported to reversibly inhibit epithelial sodium channel function in human airway epithelial cell models (IC50 = 50 nM) and to enhance mucociliary clearance for up to five hours when administered by aerosol inhalation to sheep.2 |
| 别名 | Foipan;FOY 305; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gibo, J.,Ito, T.,Kawabe, K., et al. Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity. Lab Invest. 85(1), 75-89 (2005).
2.Coote, K.,Atherton-Watson, H.C.,Sugar, R., et al. Camostat attenuates airway epithelial sodium channel function in vivo through the inhibition of a channel-activating protease. Journal of Pharmacology and Experimental Therapeutics 329(2), 764-774 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 494.5 |
| 分子式 | C20H22N4O5 • CH3SO3H |
| CAS号 | 59721-29-8 |
| 稳定性 | ≥ 2 years |
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