Prostaglandin F2α methyl ester
货号：
16011-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 16011-500ug |
| 描述 | Prostaglandin F2α methyl ester (PGF2α methyl ester) is an analog of PGF2α in which the C-1 carboxyl group has been esterified as the methyl ester. PGF2α methyl ester was one of the first PG esters shown to have ocular hypotensive activity.1 This compound continues to be a standard by which other ocular hypotensive PG prodrugs are evaluated. The methyl ester is about 4-5 times more potent than the free acid, PGF2α. This difference is attributed to improved corneal penetration, and a depot effect of prolonged retention of the ester form of the compound in ocular tissue. A 2.5 µg dose of PGF2α-OMe applied to the eyes of cats results in a 6-8 mm Hg reduction in IOP.1 |
| 别名 | PGF2α methyl ester; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bito, L.Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Experimental Eye Research 38, 181-184 (1984).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 368.5 |
| 分子式 | C21H36O5 |
| CAS号 | 33854-16-9 |
| 稳定性 | ≥ 1 year |
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