L-Leucyl-L-Leucine methyl ester (hydrochloride)
货号：
16008-100mg 基本售价：
350.0 元 规格：
100 mg
产品信息
概述| 货号 | 16008-100mg |
| 描述 | L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells.1,2 It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells.2 Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.2 |
| 别名 | LLME;LLOMe; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ohlin, M.,Danielsson, L.,Carlsson, R., et al. The effect of leucyl-leucine methyl ester on proliferation and Ig secretion of EBV-transformed human B lymphocytes. Immunology 66(4), 485-490 (1989).
2.Thiele, D.L. and Lipsky, P.E. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: Dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proceedings of the National Academy of Sciences of the United States of America 87(1), 83-87 (1990).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 294.8 |
| 分子式 | C13H26N2O3 • HCl |
| CAS号 | 6491-83-4 |
| 稳定性 | ≥ 2 years |
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