Calpain Inhibitor II
货号：
15994-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 15994-1mg |
| 描述 | Calpain inhibitor II is a cell permeable, peptide aldehyde inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM).1 It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems.2,3 |
| 别名 | Ac-Leu-Leu-Met-H;ALLM; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sasaki, T.,Kishi, M.,Saito, M., et al. Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. Journal of Enzyme Inhibition 3(3), 195-201 (1990).
2.Ravid, T.,Doolman, R.,Avner, R., et al. The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The Journal of Biological Chemisty 275(46), 35840-35847 (2000).
3.Stangl, V.,Lorenz, M.,Meiners, S., et al. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. The FASEB Journal 18(2), 272-279 (2004).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 401.6 |
| 分子式 | C19H35N5O4S |
| CAS号 | 110115-07-6 |
| 稳定性 | ≥ 2 years |
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