| 货号 | 15989-250mg |
| 描述 | Lofexidine is an α2-adrenergic receptor agonist (Kd = 7.6 nM for rat cerebral cortex membranes) that has transient antihypertensive effects.1,2 It is used in managing opioid withdrawal symptoms during detoxification from heroin (Item No. 9001543) and methadone.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jarrott, B.,Louis, W.J. and Summers, R.J. Characterization of central α-adrenoceptors using 3H-clonidine and its derivatives. Chest 83(2 Suppl), 339-340 (1983). 2.Bennett, D.A. and Lal, H. Discriminative stimuli produced by clonidine: An investigation of the possible relationship to adrenoceptor stimulation and hypotension. Journal of Pharmacology and Experimental Therapeutics 223(3), 642-648 (1982). 3.Ling, W.,Mooney, L.,Zhao, M., et al. Selective review and commentary on emerging pharmacotherapies for opioid addiction. Subst.Abuse Rehabil. 2, 181-188 (2011). 4.Gerra, G.,Zaimovic, A.,Giusti, F., et al. Lofexidine versus clonidine in rapid opiate detoxification. J.Subst.Abuse Treat. 21(1), 11-17 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 295.6 |
| 分子式 | C11H12Cl2N2O • HCl |
| CAS号 | 21498-08-8 |
| 稳定性 | ≥ 2 years |
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