TZ9
货号：
15964-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 15964-1mg |
| 描述 | TZ9 is a cell-permeable triazine compound that inhibits the human E2 ubiquitin-conjugating enzyme Rad6B.1 TZ9 selectively docks to the Rad6B catalytic site, inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2/M arrest and apoptosis, and inhibits proliferation and migration of metastatic human breast cancer cells (IC50 = 6 µM).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sanders, M.A.,Brahemi, G.,Nangia-Makker, P., et al. Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identification, and functional characterization. Molecular Cancer Therapeutics 12(4), 373-383 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 366.3 |
| 分子式 | C17H14N6O4 |
| CAS号 | 1002789-86-7 |
| 稳定性 | ≥ 2 years |
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