| 货号 | 15949-500mg |
| 描述 | Clonidine is a centrally acting α2-adrenergic receptor agonist that decreases peripheral vascular resistance by centrally inhibiting sympathetic nerve activity.1 In isolated mesenteric arteries precontracted with norepinephrine, clonidine induces relaxation at 10 µM.2 It can also open K+ channels and hyperpolarize mensenteric artery plasma membrane at this concentration.2 The antihypertensive effects of clonidine have also been attributed to its agonism of the imidazoline (I1) receptor (Ki = 4-8 nM), which mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure.3,4 |
| 别名 | Catapres;Kapvay®;ST 155; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.van Zwieten, P.A. Pharmacology of centrally acting hypotensive drugs. British Journal of Clinical Pharmacology 10(Suppl 1), 13S-20S (1980). 2.Silva, E.G.,Feres, T.,Vianna, L.M., et al. Dual effect of clonidine on mesenteric artery adrenoceptors: Agonistic (alpha-2) and antagonistic (alpha-1). Journal of Pharmacology and Experimental Therapeutics 277(2), 872-876 (1996). 3.Reis, D.J. and Piletz, J.E. The imidazoline receptor in control of blood pressure by clonidine and allied drugs. American Journal of Physiology 273(5 Pt 2), R1569-R1571 (1997). 4.Guyenet, P.G. Is the hypotensive effect of clonidine and related drugs due to imidazoline binding sites? American Journal of Physiology 273(2 Pt 5), R1580-R1584 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 266.6 |
| 分子式 | C9H9Cl2N3 • HCl |
| CAS号 | 4205-91-8 |
| 稳定性 | ≥ 2 years |
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