ERK Inhibitor
货号：
15944-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 15944-500ug |
| 描述 | ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 µM).1 This prevents its interaction with protein substrates without inhibiting catalytic activity.1 ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2.1 Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 µM), A549 lung carcinoma cells (IC50 = 25 µM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.1 |
| 别名 | Extracellular Regulated Kinase Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hancock, C.N.,Macias, A.,Lee, E.K., et al. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. Journal of Medicinal Chemistry 48(14), 4586-4595 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 328.8 |
| 分子式 | C14H16N2O3S • HCl |
| CAS号 | 1049738-54-6 |
| 稳定性 | ≥ 2 years |
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