| 货号 | 15925-10mg |
| 描述 | Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively).1,2 This inhibition is irreversible.1 Clorgyline is without effect on serotonin (Item No. 14332) receptors, but it does inhibit the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM).3,4 As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety.1,5 |
| 别名 | N-2,4-Dichlorophenoxypropyl-N-methylpropargylamine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Abdelhafez, O.M.,Amin, K.M.,Ali, H.I., et al. Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors. Journal of Medicinal Chemistry 55(23), 10424-10436 (2012). 2.Mazouz, F.,Gueddari, S.,Burstein, C., et al. 5-[4-(Benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: New reversible, highly potent, and selective monoamine oxidase type B inhibitors. Journal of Medicinal Chemistry 36(9), 1157-1167 (1993). 3.Pälvimäki, E.P.,Roth, B.L.,Majasuo, H., et al. Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2C receptor. Psychopharmacology (Berl) 126(3), 234-240 (1996). 4.Ganapathy, M.E.,Prasad, P.D.,Huang, W., et al. Molecular and ligand-binding characterization of the σ-receptor in the Jurkat human T lymphocyte cell line. Journal of Pharmacology and Experimental Therapeutics 289(1), 251-260 (1999). 5.La Regina, G.,Silvestri, R.,Gatti, V., et al. Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorganic & Medicinal Chemistry 16(22), 9729-9740 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 308.6 |
| 分子式 | C13H15Cl2NO • HCl |
| CAS号 | 17780-75-5 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |