| 货号 | 15923-1mg |
| 描述 | Caspofungin is an antifungal compound that is classified as an echinocandin, as it acts by noncompetititvely inhibiting the enzyme 1,3-β glucan synthase and preventing the synthesis of glucan in the fungal cell wall.1 It is effective against disseminated or invasive aspergillosis and candidiasis in mice and in humans.2,3 Caspofungin has a 50% minimum effective concentration against Aspergillus spp. of 0.015 µg/ml.4 It does not antagonize other antifungal compounds, like amphotericin B, and, in some cases, may show additive or synergistic activity.1,3,5 Caspofungin achieves peak concentration in neonates and infants that are comparable to those in adults and displays a favorable safety profile.6 |
| 别名 | L-743,872;MK 0991; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Letscher-Bru, V. and Herbrecht, R. Caspofungin: The first representative of a new antifungal class. Journal of Antimicrobial Chemotherapy 51(3), 513-521 (2003). 2.Abruzzo, G.K.,Flattery, A.M.,Gill, C.J., et al. Evaluation of the echinocandin antifungal MK-0991 (L-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis. Antimicrobial Agents and Chemotherapy 41(11), 2333-2338 (1997). 3.Deresinski, S.C. and Stevens, D.A. Caspofungin. Clinical Infectious Diseases 36(11), 1445-1457 (2003). 4.Pfaller, M.A.,Boyken, L.,Hollis, R.J., et al. In vitro susceptibility of clinical isolates of Aspergillus spp. to anidulafungin, caspofungin, and micafungin: A head-to-head comparison using the CLSI M38-A2 broth microdilution method. Journal of Clinical Microbiology 47(10), 3323-3325 (2009). 5.Herbrecht, R.,Nivoix, Y.,Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole. J. Antimicrob. Chemother. 56(Suppl 1), i39-i48 (2005). 6.Roberts, J.K.,Stockmann, C.,Constance, J.E., et al. Pharmacokinetics and pharmacodynamics of antibacterials, antifungals, and antivirals used most frequently in neonates and infants. Clinical Pharmacokinetics 53(7), 581-610 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 1213.4 |
| 分子式 | C52H88N10O15 • 2C2H4O2 |
| CAS号 | 179463-17-3 |
| 稳定性 | ≥ 2 years |
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