Trimipramine (maleate)
货号：
15921-1g 基本售价：
350.0 元 规格：
1 g
产品信息
概述| 货号 | 15921-1g |
| 描述 | Trimipramine (maleate) is a tricyclic antidepressant compound that antagonizes several types of neurotransmitter receptors. It is a potent antagonist of histamine H1(Kd = 0.27 nM), serotonin 5-HT2A, and α1-adrenergic (Kd = 24 nM) receptors.1 It demonstrates moderate antagonist activity at dopamine D2(Kd = 180 nM) and muscarinic acetylcholine (Kd = 58 nM) receptors and weak activity at 5-HT2C, D1, α2-adrenergic (Kd = 680 nM) receptors.1 Trimipramine (maleate) is a weak to moderate reuptake inhibitor of serotonin (Ki = 149 nM for SERT), and an extremely weak inhibitor of norepinephrine (Ki = 2.5 µM for NET) and dopamine (Ki = 3.8 µM for DAT) reuptake in slices of rat cerebral cortex.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Richelson, E. and Nelson, A. Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. Journal of Pharmacology and Experimental Therapeutics 230(1), 94-102 (1984).
2.Gross, G.,Xin, X. and Gastpar, M. Trimipramine: pharmacological reevaluation and comparison with clozapine. Neuropharmacology 30(11), 1159-1166 (1991).
3.Tatsumi, M.,Groshan, K.,Blakely, R.D., et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. European Journal of Pharmacology 340(2-3), 249-258 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 410.5 |
| 分子式 | C20H26N2 • C4H4O4 |
| CAS号 | 521-78-8 |
| 稳定性 | ≥ 2 years |
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