| 货号 | 15904-10mg |
| 描述 | Nortriptyline is a tricyclic antidepressant that blocks norepinephrine and serotonin (Item No. 14332) transporters (KDs = 4.4 and 18 nM, respectively) more potently than the dopamine transporter (KD = 1.1 µM).1 It also antagonizes serotonin, histamine, muscarinic, and α-adrenergic receptors (Kis = 5.0, 8.5, 10, 40, and 60 nM for 5-HT2A, 5-HT2C, H1, α1, and M1 receptors, respectively).2,3,4,5 |
| 别名 | Acetexa;Pamelor®; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tatsumi, M.,Groshan, K.,Blakely, R.D., et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. European Journal of Pharmacology 340(2-3), 249-258 (1997). 2.Pälvimäki, E.P.,Roth, B.L.,Majasuo, H., et al. Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2C receptor. Psychopharmacology (Berl) 126(3), 234-240 (1996). 3.Richelson, E. and Nelson, A. Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. Journal of Pharmacology and Experimental Therapeutics 230(1), 94-102 (1984). 4.Stanton, T.,Bolden-Watson, C.,Cusack, B., et al. Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics. Biochemical Pharmacology 45(11), 2352-2354 (1993). 5.Cusack, B.,Nelson, A. and Richelson, E. Binding of antidepressants to human brain receptors: Focus on newer generation compounds. Psychopharmacology (Berl) 114(4), 559-565 (1994). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 299.8 |
| 分子式 | C19H21N • HCl |
| CAS号 | 894-71-3 |
| 稳定性 | ≥ 2 years |
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