| 货号 | 15892-50mg |
| 描述 | Maprotiline is a norepinephrine reuptake inhibitor that binds the norepinephrine transporter with a KD value of 11.1 nM.1 Comparatively, it only weakly associates with serotonin and dopamine transporters (KDs = 5.8 and 1 µM, respectively).1 However, maprotiline moderately inhibits serotonin 5-HT2A receptors with a Ki value of 51 nM.2 Maprotiline has also been reported to bind the histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors with KD values of 2, 570, 90, and 350 nM, respectively.3 It has been used in the treatment of depression and also has been reported to possess sedative, anxiolytic, and sympathomimetic activities.4,5 |
| 别名 | Deprilept;Ludiomil™; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tatsumi, M.,Groshan, K.,Blakely, R.D., et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. European Journal of Pharmacology 340(2-3), 249-258 (1997). 2.Pälvimäki, E.P.,Roth, B.L.,Majasuo, H., et al. Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2C receptor. Psychopharmacology (Berl) 126(3), 234-240 (1996). 3.Richelson, E. and Nelson, A. Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. Journal of Pharmacology and Experimental Therapeutics 230(1), 94-102 (1984). 4.Rana, S.,Uralets, V.P. and Ross, W. A new method for simultaneous determination of cyclic antidepressants and their metabolites in urine using enzymatic hydrolysis and fast GC-MS. J.Anal.Toxicol. 32(5), 355-363 (2008). 5.Spencer, P.S. Review of the pharmacology of existing antidepressants. British Journal of Clinical Pharmacology 4(Suppl 2), 57S-68S (1977). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 313.9 |
| 分子式 | C20H23N • HCl |
| CAS号 | 10347-81-6 |
| 稳定性 | ≥ 2 years |
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