| 货号 | 15867-1mg |
| 描述 | Fialuridine (FIAU) is a nucleoside analog with antiviral activity. It inhibits thymidine kinases from herpes simplex virus types 1 and 2 with Ki values of 0.14 and 0.95 µM, respectively, while blocking green monkey Vero cell thymidine kinase less effectively (Ki = 53 µM).1 FIAU blocks DNA synthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex.2,3,4 Notably, while FIAU has few adverse effects in several mammals, it causes mitochondrial toxicity leading to liver damage and death in humans.5 |
| 别名 | FIAU;Fluoroiodoarauracil;5-Iodo-2’-Fluoroarauracil;NSC 678514; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mansuri, M.M.,Ghazzouli, I.,Chen, M.S., et al. 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent. Journal of Medicinal Chemistry 30(5), 867-871 (1987). 2.Colacino, J.M. and Lopez, C. Efficacy and selectivity of some nucleoside analogs as anti-human cytomegalovirus agents. Antimicrobial Agents and Chemotherapy 24(4), 505-508 (1983). 3.Staschke, K.A.,Colacino, J.M.,Mabry, T.E., et al. The in vitro anti-hepatitis B virus activity of FIAU [1-(2-deoxy-2-fluoro-1-β-D-arabinofuranosyl-5-iodo)uracil] is selective, reversible, and determined, at least in part, by the host cell. Antiviral Res. 23(1), 45-61 (1994). 4.Watanabe, K.A.,Reichman, U.,Hirota, K., et al. Nucleosides. 110. Synthesis and antiherpes virus activity of some 2-fluoro-2-deoxyarabinofuranosylpyrimidine nucleosides. Journal of Medicinal Chemistry 22(1), 21-24 (1979). 5.Attarwala, H. TGN1412: From Discovery to Disaster. J.Young Pharm. 2(3), 332-336 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 372.1 |
| 分子式 | C9H10FIN2O5 |
| CAS号 | 69123-98-4 |
| 稳定性 | ≥ 2 years |
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