| 货号 | 15774-250mg |
| 描述 | 6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity.1,2 Upon incorporation into DNA, 6-TG has been shown to disrupt cytosine methylation by DNA methyltransferases, interfering with the epigenetic pathway of gene regulation.3,4 This compound has been used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors.5 |
| 别名 | NSC 752;NSC 76504;6-TG; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bohon, J. and de los Santos, C.R. Effect of 6-thioguanine on the stability of duplex DNA. Nucleic Acids Research 33(9), 2880-2886 (2005). 2.LePage, G.A. Incorporation of 6-thioguanine into nucleic acids. Cancer Research 20, 403-408 (1960). 3.Wang, H. and Wang, Y. 6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry 48(10), 2290-2299 (2009). 4.Yuan, B.,Zhang, J.,Wang, H., et al. 6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1. Cancer Research 71(5), 1904-1911 (2011). 5.Issaeva, N.,Thomas, H.D.,Djureinovic, T., et al. 6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. Cancer Research 70(15), 6268-6276 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 167.9 |
| 分子式 | C5H5N5S |
| CAS号 | 154-42-7 |
| 稳定性 | ≥ 2 years |
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