| 货号 | 15617-10mg |
| 描述 | Fluvoxamine selectively inhibits the reuptake of serotonin (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM), resulting in decreased serotonin turnover in the brain.1,2 By potentiating the pharmacological effects of serotonin and its precursor, 5-hydroxy tryptophan, in the central nervous system, fluvoxamine is known to exhibit antidepressant effects.2 At higher concentrations, fluvoxamine can block the activity of HERG channels (IC50 = 3.8 µM), which carry the delayed rectifier potassium current that is important for repolarization of ventricular action potentials over the course of normal cardiac functioning.3 It also has been reported to exhibit cardioprotective effects by stimulating the σ1receptor.4 |
| 别名 | Fevarin;Floxyfral;Luvox®;MK-264;NSC 309469; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Claassen, V.,Davies, J.E.,Hertting, G., et al. Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. British Journal of Pharmacology 60(4), 505-516 (1977). 2.Hrdina, P.D. Pharmacology of serotonin uptake inhibitors: Focus on fluvoxamine. J.Psychiatry Neurosci. 16(2 Suppl. 1), 10-18 (1991). 3.Mitcheson, J.S. Drug binding to HERG channels: Evidence for a non-aromatic binding site for fluvoxamine. British Journal of Pharmacology 139(5), 883-884 (2003). 4.Tagashira, H. and Fukunaga, K. Cardioprotective effect of fluvoxamine, sigma-1 receptor high affinity agonist. Yakugaku Zasshi 132(2), 167-172 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 434.4 |
| 分子式 | C15H21F3N2O2 • C4H4O4 |
| CAS号 | 61718-82-9 |
| 稳定性 | ≥ 2 years |
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