2-Chloroadenosine
货号：
15612-10mg 基本售价：
350.0 元 规格：
10 mg
产品信息
概述| 货号 | 15612-10mg |
| 描述 | 2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1,900 nM, respectively.1 CADO has been used to activate adenosine receptors in the thalamus, generating anticonvulsive activity in a rat model of generalized seizures.2 It has also been used to induce bronchoconstrictor effects in a guinea pig model of asthma and to study cardiovascular responses in normotensive and hypertensive rats.3,1 |
| 别名 | Antibiotic AT-265B;CADO;NSC 36896; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mathôt, R.A.A.,Soudijn, W.,Breimer, D.D., et al. Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo. British Journal of Pharmacology 118(2), 369-377 (1996).
2.Ates, N.,Ilbay, G. and Sahin, D. Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine application. Experimental Biology and Medicine 230(7), 501-505 (2005).
3.Manzini, S. and Ballati, L. 2-Chloroadenosine induction of vagally-mediated and atropine-resistant bronchomotor responses in anaesthetized guinea-pigs. British Journal of Pharmacology 100(2), 251-256 (1990).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 301.7 |
| 分子式 | C10H12ClN5O4 |
| CAS号 | 146-77-0 |
| 稳定性 | ≥ 2 years |
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