| 货号 | 15596-50mg |
| 描述 | Rauwolscine is a natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM).1 It is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors.1 Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM) and as a weak partial agonist at 5-HT1A(IC50 = 1.3 µM).2,3,4 The α2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior.5,6 |
| 别名 | Isoyohimbine;NSC 407307;α-Yohimbine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Perry, B.D. and UPrichard, D.C. [3H]rauwolscine (α-yohimbine): A specific antagonist radioligand for brain α2-adrenergic receptors. European Journal of Pharmacology 76(4), 461-464 (1981). 2.Kaumann, A.J. Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors. Naunyn-Schmiedebergs Archives of Pharmacology 323(2), 149-154 (1983). 3.Arthur, J.M.,Casañas, S.J. and Raymond, J.R. Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors. Biochemical Pharmacology 45(11), 2337-2341 (1993). 4.Wainscott, D.B.,Sasso, D.A.,Kursar, J.D., et al. [3H]Rauwolscine: An antagonist radioligand for the cloned human 5-hydroxytryptamine2B (5-HT2B) receptor. Naunyn-Schmiedebergs Archives of Pharmacology 357(1), 17-24 (1998). 5.Brede, M.,Philipp, M.,Knaus, A., et al. α2-adrenergic receptor subtypes - novel functions uncovered in gene-targeted mouse models. Biology of the Cell 96(5), 343-348 (2004). 6.Cottingham, C. and Wang, Q. α2 adrenergic receptor dysregulation in depressive disorders: Implications for the neurobiology of depression and antidepressant therapy. Neuroscience and Biobehavioral Reviews 36(10), 2214-2225 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.9 |
| 分子式 | C21H26N2O3 • HCl |
| CAS号 | 6211-32-1 |
| 稳定性 | ≥ 2 years |
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