| 货号 | 15582-5mg |
| 描述 | Dobutamine is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo.1,2,3 It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions.1,2 As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects.1 Dobutamine is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 μM.4 |
| 别名 | Dobutrex;Inotrex;NSC 299583; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tuttle, R.R. and Mills, J. Dobutamine: Development of a new catecholamine to selectively increase cardiac contractility. Circulation Research 36(1), 185-196 (1975). 2.Deighton, N.M.,Motomura, A.,Bals, S., et al. Characterization of theβadrenoceptor subtype(s) mediating the positive inotropic effects of epinine, dopamine, dobutamine, denopamine and xamoterol in isolated human right atrium. Journal of Pharmacology and Experimental Therapeutics 262(2), 532-538 (1992). 3.Brown, L.,Näbauer, M. and Erdmann, E. Dobutamine: Positive inotropy by nonselective adrenoceptor agonism in isolated guinea pig and human myocardium. Naunyn-Schmiedebergs Archives of Pharmacology 335(4), 385-390 (1987). 4.Innocenti, A.,Gülçin, I.,Scozzafava, A., et al. Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorganic & Medicinal Chemistry Letters 20(17), 5050-5053 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 337.9 |
| 分子式 | C18H23NO3 • HCl |
| CAS号 | 49745-95-1 |
| 稳定性 | ≥ 2 years |
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