| 货号 | 15553-1mg |
| 描述 | ON-01910 is a potent, non-ATP-competitive inhibitor of polo-like kinase 1 (Plk1; IC50 = 9 nM), a serine/threonine protein kinase involved in the regulation of cell cycling.1 It induces apoptosis in a wide array of tumor cell lines (GI50 = 50-200 nM) and blocks the growth of multidrug resistant cancer cell lines.1,2,3,4 ON-01910 is active in vivo when administered intraperitoneally and synergizes with chemotherapeutic agents, preventing tumor growth or abolishing tumors in human xenograft nude mouse models.1 |
| 别名 | Rigosertib; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Gumireddy, K.,Reddy, M.V.R.,Cosenza, S.C., et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell 7(3), 275-286 (2005). 2.Chapman, C.M.,Sun, X.,Roschewski, M., et al. ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clinical Cancer Research 18(7), 1979-1991 (2012). 3.Oussenko, I.A.,Holland, J.F.,Reddy, E.P., et al. Effect of ON 01910.Na, an anticancer mitotic inhibitor, on cell-cycle progression correlates with RanGAP1 hyperphosphorylation. Cancer Research 71(14), 4968-4976 (2011). 4.Chang, K.C.,Chang, W.C.,Chang, Y., et al. Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma. PLoS One 8(11), 1-12 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 473.5 |
| 分子式 | C21H25NO8S • Na |
| CAS号 | 1225497-78-8 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |