| 货号 | 15539-5mg |
| 描述 | Bradykinin is a 9-amino acid peptide that dilates blood vessels and consequently reduces blood pressure by inducing the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor.1,2,3 It also contracts non-vascular smooth muscle in the bronchus and gastrointestinal tract, increases vascular permeability, and is involved in the mechanism of pain mediation.4,5,6 The discovery of bradykinin-potentiating peptides from snake venom led to the discovery of a class of highly-effective anti-hypertensive drugs, the ACE inhibitors, which have been shown to prevent angiotensin-converting enzyme’s inactivation of bradykinin.7 |
| 别名 | H 1970; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Barrow, S.E.,Dollery, C.T.,Heavey, D.J., et al. Effect of vasoactive peptides on prostacyclin synthesis in man. British Journal of Pharmacology 87, 243-247 (1986). 2.Campbell, W.B.,Falck, J.R. and Gauthier, K. Role of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factor in bovine coronary ateries. Medical Science Monitor 7(4), 578-584 (2001). 3.Ju, H.,Venema, V.J.,Marrero, M.B., et al. Inhibitory interactions of the bradykinin b2 receptor with endothelial nitric-oxide synthase. The Journal of Biological Chemisty 273, 24025-24029 (1998). 4.Dray, A. and Read, S.J. Future targets to control osteoarthritis pain. Arthritis Research & Therapy 9, 212-225 (2007). 5.Figini, M.,Emanueli, C.,Grady, E.F., et al. Substance P and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas. American Journal of Physiology 272, G785-G793 (1997). 6.Heavey, D.J.,Barrow, S.E.,Hickling, N.E., et al. Aspirin causes short-lived inhibition of bradykinin-stimulated prostacyclin production in man. Nature 318, 186-188 (1985). 7.Cushman, D.W. and Ondetti, M.A. Design of angiotensin converting enzyme inhibitors. Nature Medicine 5(10), 1110-1113 (1999). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1120.3 |
| 分子式 | C50H73N15O11 • XC2H4O2 |
| CAS号 | 1806553 |
| 稳定性 | ≥ 1 year |
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